Recently, researchers from Harbin Medical University and other departments used bioinformatics methods for the first time to identify the high-throughput relationship between small molecule compounds and miRNA in human cancer. The relevant results were published in the "Scientific Reports" magazine of Nature Press on.
miRNA is a single-stranded non-coding RNA that participates in a variety of biological processes closely related to human cancer, such as cell proliferation, differentiation, and apoptosis. Recent studies have found that miRNA can be targeted by chemical small molecules, and has received more and more attention. Using small molecular compounds to target miRNA will become a new type of cancer treatment method.
The researchers used bioinformatics to identify the high-throughput relationship between small molecular compounds and miRNAs in human cancer. Based on information such as gene chip data perturbed by small molecules, differentially expressed genes in cancer, and target genes regulated by miRNA, a network of small molecules and miRNAs was constructed in 17 human cancers.
After further analysis of the network, the researchers also determined the functional characteristics of small molecule modules and miRNA modules, and successfully applied to the screening of candidate drugs and the relocation of drugs. The results of the study found that trichostatin A (TSA) may have a broad-spectrum anticancer effect. At the same time, the association between TSA and miR-19a, miR-19b, miR-23b has the highest frequency among all cancers. Path analysis of these three miRNA common target genes revealed that they were significantly enriched in the MAPK signaling pathway and mTOR signaling pathway, which suggests that TSA may play an anticancer role by regulating these two signaling pathways.
In addition, the analysis also pointed out that 2-deoxy-D-glucose (2DOG) has the potential to become a candidate anticancer drug and that estradiol may have anti-inflammatory activity. The results of this research will greatly accelerate the development of miRNA-related drugs, provide safer and more efficient drug candidates for cancer treatment, and will also provide important reference and help for personalized medicine for cancer patients.
The corresponding author of the article is Professor Li Xia of Harbin Medical University. The first author is associate professor Jiang Wei, a postdoctoral fellow under the guidance of Academician Yang Baofeng. The two research groups collaborated to analyze the association between small molecules and miRNAs in human cancer based on transcriptional responses.
Professor Li Xia has been engaged in research in the field of bioinformatics for many years, the main research directions are: molecular typing and biomarker recognition of complex and major diseases based on biospectrum; bioinformatics fusion analysis technology; molecular biological network (SNPs virtual network, gene regulation) Network, miRNA-mRNA cooperative regulatory network, protein interaction network, etc.) reconstruction; miRNA and complex disease regulation mechanism research; complex disease risk pathway identification technology; gene and protein function research biochip information analysis technology; high Flux drug molecular target screening technology; research and development of bioinformatics methods and analysis platforms to analyze the molecular mechanism of cancer.
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