The newspaper London, October 17th (Reporter Liu Haiying) Researchers at Imperial College London in the United Kingdom published a paper in the latest issue of "Natural Medicine" magazine that they found that the level of an enzyme called SGK1 in women's endometrium may Directly affect women's fertility, too high content will lead to infertility, too low content will easily lead to miscarriage. The discovery not only contributes to the research and treatment of infertility or habitual abortion, but also to the development of new contraceptive drugs. Infertility is a huge problem for many families in modern society. Studies have shown that nearly one-sixth of women cause difficulties in conception due to various reasons, and after conception, 1% of women will have a habitual abortion. Researchers at Imperial College London in England studied the physiological indicators of 106 women with unexplained infertility or habitual abortion and found that their troubles were directly related to the level of SGK1 in their endometrium. Women with unexplained infertility have higher levels of SGK1 in the endometrium than ordinary people, while those with habitual abortion have lower levels of SGK1. Through further experiments in mice, the researchers found that during pregnancy, the SGK1 level in the endometrium of the mouse will decrease. If a copy of the SGK1 gene is injected into the endometrial cells of the mouse to increase the protein level, it will As a result, mice cannot be conceived; if blocking the expression of SGK1 gene in mice and lowering its level, although the mice are pregnant, it will make the endometrium more fragile, resulting in intrauterine bleeding, which will lead to miscarriage. The researchers said that SGK1, as a fertility molecular switch, its content in endometrial cells directly affects women's fertility and is the key to the success of conception. Reducing the level of SGK1 in endometrial cells by drugs before infertile women undergoing artificial conception can improve the success rate of artificial conception. Increasing the level of SGK1 can be regarded as a new method of contraception, and new contraceptive drugs can be developed accordingly.
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