"Nature-Methodology", a sub-journal of "Nature", launched the special issue of research methods in 2011 in the latest issue, and selected this year's research method-Gene-editing Nucleases. The special issue includes editorials, news features, comments, videos, etc. At the same time, it also commented on eight other research methods that deserve attention.
Genome editing nucleases are a class of genetically engineered nucleases, mainly including three categories: zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases, TALENs) and homing endonucleases (engineered meganucleases). Genome editing nucleases can locate and accurately change biological genomes, which creates new possibilities for studying gene function and treating diseases.
Although the first ZFN was discovered ten years ago, the work in this field has made great progress in the past year. In 2011, a major breakthrough in clinical genome editing technology was achieved, and related research on TALENs also achieved new results.
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