New progress has been made in the combination of nano-gold-shell photothermotherapeutic therapy for cancer treatment

Achieving safe and effective treatment of malignant tumors is one of the major challenges in the biomedical community. Under the leadership of Researcher Tang Fangqiong, the Laboratory of Controllable Preparation and Application of Nanomaterials, Institute of Physical and Chemical Technology, Chinese Academy of Sciences, has been devoted to the design and development of new nanocarriers and their biomedical applications in recent years.

Nano-gold shell-coupled transferrin molecules carry drugs to target tumors, and photothermotherapy combined with chemotherapy kills tumor cells

The multifunctional nano-gold shell with new structure and new performance is one of the new anti-tumor nano materials that the team has been devoting to the development. The inner layer of the material is a hollow mesoporous silica with unique structure as the core (Adv. Mater. 2009, 21, 3804-3807), its surface is covered with a gold shell, and the nano-gold shell is based on its physical and chemical properties-plasma Based on the resonance properties, the near-infrared laser irradiation can convert the near-infrared laser light energy into heat energy, and it is equipped with sandwich silica to load and control the slow-release technology of various chemotherapeutic drugs, killing tumor cells with high efficiency and low toxicity. The result was published in the top journal of the international chemical community "German Applied Chemistry" (Angew. Chem. Int. Ed. 2011, 50, 891–895) in early 2011.

In order to better improve the inhibition rate of the material on malignant tumors, and at the same time, in the current near-infrared photothermal cancer treatment technology, the irradiation time is long, the irradiation intensity is large, and the irradiation needs to be repeated multiple times. New technology of coupling active targeting ligand molecule transferrin. After being coupled with targeting molecules, the nano-gold shell can achieve effective suppression of malignant tumors under the conditions of reduced irradiation time and frequency and reduced irradiation intensity. After injecting the material in the tumor model of breast cancer nude mice, the tumor can be eliminated by a single irradiation of near infrared laser. In the new research progress, they also systematically studied the safety and metabolism of the new multi-functional nano-gold shell coupling active targeting ligand molecule before and after the system. The results show that the material has good biocompatibility, and Can be metabolized from the body.

Recently, this latest research progress was published in the international material industry's top journal "Advanced Materials" (Adv. Mater. DOI: 10.1002 / adma.201103343). The reviewer believes that "multifunctional gold-shell-coated sandwich silica can combine active targeting, passive targeting, photothermal therapy and chemotherapy in synergistic treatment of cancer, and the clinical application prospect is exciting."

The research was strongly supported by the "863" project of the Ministry of Science and Technology and the National Natural Science Foundation of China.

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